-----Original Message-----
From: Gordon Seese <[log in to unmask]>
To: [log in to unmask] <[log in to unmask]>
Date: Thursday, April 15, 1999 10:37 PM
Subject: Re: Sorting out the Agonists
>At 10:43 PM 4/15/99 +0000, you wrote:
>>I think it's about time that we got a clear picture of the various
dopamine
>>agonists, since they feature in most people's drug diet these days. For
>>instance; I take Permax (Pergolide) in addition to levadopa. Over the last
>>6 years I have worked myself up from zero to 5 mg of Permax in order to
>>combat the steady deterioration which is the hallmark of PD. Now this
simple
>>fact is of very little use if I want to see into the future, unless I can
>>relate my current intake of Permax to some absolute standard. Not only
>>that, how do I relate my situation to that of someone taking say
Ropinirole
>>(Requip)? With your help, I think we can answer these questions.
>>
>>What we need is for as many members of this list as possible to complete
the
>>response form at the end of this e-mail. I have not seen this attempted
>>before (maybe it can't be done) but let's make the attempt.
>>
>>Problem areas: A key question is 'What is the maximum safe dosage of
>>whatever drug you are using?' This is bound to be a moving feast in
>>practice: for instance; when I was taking 2 mg of Permax, my neurologist
>>told me that about 4 mg would be the maximum safe level. When I reached
>>4mg , he told me that people were taking up to 12 mg. I am very grateful
>>to these pioneers for effectively opening-up my future by several years.
>>
>>If we get enough of a response to make a useful analysis I will attempt
>>to do so, and will make the data available to anyone who asks for it. Of
>>course any results will be published in the list.
>>
>>Questions:
>>
>>1/ Which Dopamine Agonist are you taking?
Mirapex
>>
>>2/ When did you start taking it?
About 9 months ago>>
>>3/ When were you diagnosed as having PD?
>> 1991
>>4/ What was your age when diagnosed?
>> 51
>>5/ When do you believe (with hindsight) that you experienced first
symptoms?
>> Age 45-46
>>6/ What is your present daily intake of levodopa? (Sinemet, Madopar)
>> 25/100 5-6 /day
>>7/ What is your present daily intake of Dopamine Agonist?
4 mg/day
>>
>>8/ Has your neurologist advised you of the max. safe dose for your
agonist?
>>
> No she just said that hern patients seem to do best on that dose as
a rule>>--
>>Brian Collins <[log in to unmask]>
>>
>>1.Mirapex
>2.1998
>3.1980
>4.52
>5.1976
>6.10/100 &25/100=7 a day, alternated
>7.Mirapex1/2 tab. 3 times =225mg
