Brian. After perusing some 40-odd responses to the subject survey I note my daily Levodopa intake is roughly twice that of the next highest respondent. Accordingly, I am submitting my responses directly to the List (cc to you) in hopes of eliciting responses from other members with high Levodopa dosages. I see a competent Movement Disorder Specialist, self medicate with his approval and maintain a fairly normal lifestyle. I can generally avoid other than mild Dyskinesia by reducing a dose by 1/2 tablet of 25/100 Sinemet. 1. Which agonist? Mirapex 2. When did you begin taking it? August, 1997 3. When was PD diagnosed? 1989 4. Age when diagnosed? 43 5. When first symptoms noted? 1986 6. Present daily intake of Levodopa? Approx. 2,000 mg. (2 X 25/100 q 2 hours plus 50 mg. kickers as needed--I average 1 kicker per day.) The formula calculates to 2400 mg. before kickers but I usually miss two late night doses due to sleep. 7. Present agonist intake? 3 X 1.5 mg.=4.5 mg daily 8. Has neuro advised of max safe dose? Yes, plus it's available on any package insert. Bob Bowling Overland Park, KS [log in to unmask]