Brian; ( response for my wife, Doris) 1. Which agonist? - Permax ( Neuro wanted to change to Mirapex, but I persuaded him to stay with Permax. To increase the dosage and to await entacapone. 2. When started. - 1997. A very, very gradual increase in dosage. An earlier experiment with Permax had proven disastrous because of very rapid increase in dosage. 3. When diagnosed. - 1993 4. Age of diagnosis. - 70 5. First symptoms. - 1990 6. Sinemet intake: - 5 x 25/100 CR; 2 X 1/2 25/100 R 7. Dopamine intake. - 3mg (to be slowly increased to 4) 8. No, - But when we asked about increasing he did mention that there are patients taking far more than she was. Jules cg for Doris, 76/6