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Hello! I'm on Comtess (Entacapone) for almost half a year now, and I've had very few side-effects from it. A bit of nausea, rather loose bowel, but on the other hand I have less gap between the doses. I went from 2x Madopar 62.5 every three hours (with considerable cramping and tremor after 2.5 hours or so), to 1.5x Madopar 62.5 every three hours. At end of dose I just have a mild stiffness coupled with manageable tremor. Really good days, I even get too much effect, and go down to 1 Madopar. (I take one Comtess 200mg with each dose of Levodopa.) John. (30 now/ 28 dx/ 18 onset) > From: <[log in to unmask]> > > To our Canadian friends, > > Am trying to locate info on Entacapone/Comtan. Is it > available in Canada to P.W.P. Does anyone have any experience with > it? Any unusual side effects.I welcome all replies. Caregiver to > Antonette 76/87/85