Hi Linda, I'm at about the same stage of life (48) and disease (dx 15 mos) as you, and I work in publishing, full-time gig, which may not be physically the challenge that nursing is. I started on CR Sinemet 50/200 early on following diagnosis cuz I couldn't function at work (hands operating computer keyboard). I'm on a small dose, 1 in the a.m. and 1/2 at noon, and I with it I take Requip 1 mg. (3Xday), another agonist like Mirapex. With my neurologist, I've experimented at different agonist dosing levels and brands, including a trial of no Sinemet, just the agonist. Didn't work. But what does work is for the agonist to smooth out and prolong the effects of the Sinemet. What's curious to me is: why stop the St. John's Wort? Best wishes, Bellingham Rick __________ Linda Potter wrote: > > Hello, all. Linda here,50 yrs. old, dx'd 11 mos. ago at age 49. Doc > started me on mirapex, increasing the dose until I got to 4.5 mg/day. > Been on this dose since Jan. As far as I remember, I started noticing > dizziness in Mar. It has been increasing, Don't have it when i wake up, > but it starts about an hr. after I take my first hand-full of meds. Meds > are mirapex, asa, premarin, provera, and St. John's Wort in the A.M. At > noon I take mirapex, S.J.W., and b-complex. Evening it's mirapex, S.J.W., > ane vit E. Saw my neuro yest., and he wanted to decrease the mirapex and > start sinemet. I gave him puppy-dog eyes and pleaded with him- said I was > really hoping to hold off longer. He relented, sort of, and said to stop > the St. John's Wort and call him in 1 month with an update.He said , as > far as my PD goes, I look good. Any ideas, thoughts, anything on this? My > mind isn't ready to accept the idea of sinemet. I still work as a nurse, > and am leery about how I'll react to it, plus, I was hoping to hold off > at least 2 years. Part of me is still in denial that I really have PD. > Maybe it's sitting in front of this computer! As you can probably tell, > I'm quite shook up about all this. Thank you all for tolerating this. > linda ------------------------------