Ever have one of those bad pill days, when it takes hours before your levodopa starts working? Here's what I mean: (view with Courier font to make columns line up) Good pill day schedule as per neurologist: Sinemet CR Regular Sinemet Eldepryl Permax 50/200 25/100 5 mg .25 7 am 1 1 1 1 11 am 1 1/2 1 1/2 3 pm 1 1/2 - 1/2 7 pm 1 1/2 - - Bad pill day, (or Where, oh where, has my Sinemet gone?): 8 am 1 1 1 1 OK, it's Saturday. The doses will be an hour later. 8:30 Breakfast - Low fat cereal with hot water instead of milk. 9:30 ON. Pill(s) kick in. 11:30 OFF. Much earlier than expected. Did the CR start working yet or not? Did it reach the small intestines where it is absorbed? Need a snack to provide evidence. noon Plain oat bran muffin to stimulate gastric activity. 12:30 ON again - Aha! That's the CR, just a bit late. 12:45 Too early for the 2nd Sinemets, so I take just the 11 am Eldepryl and the Permax. 1:00 pm Lunch: Assorted cold salad appetizers (takeout) from a nearby Turkish restaurant. Not really loaded with olive oil, but some is present. 1:15 - Start afternoon nap. That's what Saturday's for. 2:50 OFF when I wake up. 3 1 CR, 1 regular Sinemet (2nd Sinemet dose of the day). 3:30 - 4:30 Various snacks and beverages to get the old innards to move the pills out of the stomach. 5:30 ON. And so it goes. Levodopa works well enough once it gets to where it functions. The delivery mechanism stinks. Comments anyone? Phil Tompkins Hoboken NJ Age 61/dx 1990