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Ivan M Suzman wrote: > Does anyone know if Tolcapone is, in specific circumstances, to be > avoided when a Hepatitis diagnosis has occurred in the past.? > J.R.Bruman,. can you help here? Thanks, but I don't know that much about it. The very distant connection is the similarity between a few (3 I believe) recorded cases of acute fatal hepatitis associated with Tolcapone and the equally rare acute hepatitis associated with infection, principally Hepatitis B (HBV). Some authorities have remarked that persons who have previously recovered from HBV, although asymptomatic, may be more susceptible to re-infection that can reach the acute stage. Because of that close similarity I have suggested that it might be wise to screen prospective users of Tolcapone for prior HBV infection, but nothing came of it. Cheers, Joe -- J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks, CA 91403-5013