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Dr. Zunin. I was prescribed Tagamet 400 bid for 5 or 6 years for heartburn and reflux disease. Those symptoms have been adequately treated. When our military pharmacy stopped stocking Tagamet and replaced it with Zantac, my gastroenterologist wrote a script for that. My PD was only dx in l998 when Requip was prescribed, which is still my only medication, the present dose is 2 mg/3X day. I very seldom experience reflux or heartburn anymore, but I now wonder if I've been on these GI meds too long. My drug manual lists adverse reactions, among them "peripheral neuropathy," for cimetidine (Tagamet). That doesn't sound good.... Clare