Recovery of Chronic Parkinsonian Monkeys
by Autotransplants of Carotid Body Cell Aggregates into Putamen
We have studied the effect of unilateral autografts of carotid body cell
aggregates into the putamen of MPTP-treated monkeys with chronic
parkinsonism.
Two to four weeks after transplantation, the monkeys initiated a
progressive recovery of mobility with reduction of tremor and bradykinesia
and restoration of fine motor abilities on the contralateral side.
Apomorphine injections induced rotations toward the side of the transplant.
Functional recovery was accompanied by the survival of tyrosine
hydroxylase-positive (TH-positive) grafted glomus cells.
A high density of TH-immunoreactive fibers was seen reinnervating broad
regions of the ipsilateral putamen and caudate nucleus.
The nongrafted, contralateral striatum remained deafferented.
Intrastriatal autografting of carotid body tissue is a feasible technique
with beneficial effects on parkinsonian monkeys; thus, this therapeutic
approach could also be applied to treat patients with Parkinson's disease.
Neuron -- Summaries: Luquin et al. 22 (4): 743 M.
Rosario Luquin1, Rafael J. Montoro4, Javier Guillén1, Laura Saldise1,
Ricardo Insausti3, Joaquín Del Río2, José López-Barneo4
1 Departamento de Neurología, Facultad de Medicina, Universidad de Navarra,
E-31080 Pamplona, Spain
2 Departmento de Farmacología, Facultad de Medicina, Universidad de
Navarra, E-31080 Pamplona, Spain
3 Departamento de Anatomía, Facultad de Medicina, Universidad de
Castilla-La Mancha, E-02071 Albacete, Spain
4 Departamento de Fisiología Médica y Biofísica, Facultad de Medicina,
Universidad de Sevilla, E-41009 Sevilla, Spain
Corresponding author: José López-Barneo, 34 95 438 9299 (phone), 34 95 455
1769 (fax), [log in to unmask]
<http://www.neuron.org/cgi/content/abstract/22/4/743>
Neuron, Vol. 22, 743-750, April, 1999, Copyright 1999 by Cell Press
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