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Hi Dorothy, Unfortunately, I think you are likely right about the fact that Clozaril is unlikely to be helpful when the primary symptoms are related to confusion as opposed to hallucinations or delusions. But sometimes it can be worth a careful try. It can be extremely sedating and the published data on Clozaril and PD suggests that starting at half this dose or less is often effective. Also, Camilla is correct when she mentions the possibility of other drugs instead of Clozaril. since Clozaril in occasional cases can cause aplastic anemia. It might well be worthwhile to request a consultation from a psychiatrist with experience in treating PD. Good luck, Charlie Dorothy Ivankoe wrote: > My husband was diagnosed with parkinson's about 25 years ago. Other than a > bad period about 4 years ago involving paranoia we have been able to deal > with this disease. Three weeks ago his right eye was mostly closed and he > had double vision which the doctor said was from the "third nerve" and this > would last anywhere between 6 weeks and 6 months. A day or two after this > his Parkinson's worsened dramatically -- he became very confused -- unable to > find the bathroom, refrigerator, etc. > > The neurologist has put him on Clozaril which he said will help eliminate > confusion. Has anyone used this for confusion without hallucinations or > paranoia? Last night was the first night he was on it (25 mg) and it really > knocked him out. Today he has had periods of freezing which are much worse > than he ever had before. > > Would appreciate anyone sharing your experience with this drug. > > Dorothy Ivankoe > (husband Roy) /68/43/41 -- ****************************************************************************************** Charles T. Meyer, M.D. Middleton (Madison), Wisconsin [log in to unmask] ******************************************************************************************