Ed: Two experiences my husband has had in the past l2 yr - l. Started on cogentin for tremor (only med. for two years) and tried to reduce when began Sinimet but he still takes 2X.5mg/day - when he tries to not take any his tremors increase- other- wise no problem with tremors. 2. He's always taken meds spread evenly over a 24 hr. period. Takes middle of night dose when gets up for bathroom anyway - about 2 A.M. give or take 1 hr. The interruption is well worth the benefits and he has had very few episodes of disturbing cramps or rigidity. He tried to take a daily schedule ( as recommended by the Dr.) three times, always with poor results - so we stay with the tried and true method. Just a couple things to consider - hope things go better for Jack , whatever, you decide to do..... Marie Carepartner for husband 69/l2