Bob, The NIH does give some information on its' web site about how it's money is spent - but it sure doesn't make it easy to find, and it's not very detailed. It's under the ofm - Office of Fiscal (or Financial?) Management - Congressional Justification section. The URL is http://www4.od.nih.gov/ofm/cj/overview.htm It includes the general areas of research the NIH will be focusing on. If you go to "Funding by Selected Categories" there is a breakdown of funding by INstitute and also specific disease for 1998 -2000 (est.) I think the 2000 numbers are based on the President's budget, so are subject to change bt Congress. For PD funding it shows: 1999 total - 127 million 2000 total - 132 million Direct - 78 million Direct - 81 million Indirect - 49 million Indirect - 50 million It doesn't explain what is meant by "direct" and "Indirect." PD is the only disease that is broken down like this. Even more interesting is an explanation of how the NIH FY 1999 increase of $2,030 million was spent. (this is just the increase - not the total budget) I think this accounting was required by Congress last year. For this go to http://www4.od.nih.gov/ofm/policies/page1.htm for a series of charts and http://www4.od.nih.gov/ofm/policies/narrative.htm for an "Expanded narrative for FY 1999 Budget." I looked for anything about PD - there's not too much listed, or maybe I missed it. 55% of the NIH increase went to fund Research Project Grants -$1,116 million Among the "Selected Programs" listed here were "New technologies for analyzing gene expression in the nervous system" "Gene expression patterns in aging and neurodegeneration processes" "Expanded neuroinformatics for the HUman Brain Project" - these were the closest to PD research among about 50 projects listed here - wonder if this is what they mean by "Indirect?" or were the PD grants just not among the "Selected?" I kept hoping to find a project called "Finding a Cure for Parkinson's." Slide 8 listed "Selected programs - Centers" and here Parkinson's Disease Research Centers of Excellent were listed - but no dollar amount or number of funded centers - wasn' t it to be five? Does anyone know more about what is being funded in 1999 for PD research and what is going on with this year's budget appropriations process? Linda