Hi ! Titration, according to Taber's, is the "EStimation of the concentration of a chemical solution by adding known amounts of standard until alteration in color or electrical state occurs." The careful titration takes time. In medicine, getting the most effective dosage ,especially when changing from one drug to another , requires monitoring of blood levels during gradual changes of medication. The occurence of "ON"and "OFF" periods is one method of monitoring.. For example, my doctor, a noted neurologist and movement disorder specialist, in reducing my Sinemet, had me cut the dosge by one-half pill for two weeks,then another one-half for two weeks,then wait,, and so on. Of course, we are individually different in our aborption and utilization,. I'm just trying to illustrate how we must rely on our doctors or specialists for advice. And I'm not a professional. But I do think Michel Margosis is correct when he says in "Mirapex Titraion ???" 0099-05-06 00-50-40 EDT, >My two cents sa C.G. layman is >a. check with the package insert for all such information , i.e. > chemistry pharmacology, adverse reactions, etc.etc. >b. verify with acompetent neurologist who is a movement disorder > specalist, and then > listen to him/her. The specilist is far better equipped to > answer your questions >than we are. >Good luck,and good titer ! >Michel Margosis [log in to unmask] (Mary Manfredi) PS TYpos are mine ( 2 fingerers)