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Nita: I have resisted joining in on the pre-curser symptoms discussion because my father has been diagnosed with MSA, not "regular" PD. However, your question about anemia really strikes a chord. In hindsight, Dad seems to have had many of these pre-dx symptoms. He lived on Mylanta due to chronic constipation. His right shoulder was visibly dropping. He first saw a doctor when he began to feel unusually tired. This really bothered him since he was a very serious athelete. The heart work up showed nothing, but blood tests showed an iron deficiency. Iron pills didn't help. He had to go through the upper and lower GI series as they looked for signs of internal bleeding, but nothing appeared. Finally, after nearly a year of tests and declining abilities, the GP gave him some sinemet to try. That didn't help much, except to cure the constipation! We have continued to chase the doctors, take tests and try a myriad of drugs for another year & 1/2, finally arriving at the MSA diagnosis. Meanwhile, he still has an iron deficiency which is not responsive to iron supplements. Go figure! Jane Koenig Marietta, GA (daughter of Fred, 80/1 1/2)