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Apoptotic mechanisms in neurodegeneration: possible relevance to glaucoma. Deprenyl, a monoamine oxidase inhibitor used in the treatment of Parkinson's disease, along with its primary metabolite desmethyldeprenyl (DES) have been shown to reduce neuronal apoptosis by a mechanism that requires gene transcription and involves the maintenance of mitochondrial membrane potential. This review article explores the mechanisms by which DES maintains mitochondrial membrane potential. Mediated by GAPDH binding, DES increases mitochondrial BCL-2 and BCL-xL levels and decreases BAX levels thereby preventing the permeability transition pore (PTP) form opening and preventing apoptotic degradation. The favorable effects of deprenyl on neuronal apoptosis suggests the therapeutic potential of designing compounds with the capacity to alter the configurations of pro-apoptosis or anti-apoptotic proteins. PMID: 10230602, UI: 99247217 Tatton WG Eur J Ophthalmol 1999 Jan-Mar;9 Suppl 1:S22-9 Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA. [log in to unmask] http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10230602&form=6&db=m &Dopt=b ------------------------------------------------------------ janet paterson 52 now 41 dx 37 onset [log in to unmask] 613-256-8340 PO Box 171 Almonte Ontario K0A 1A0 Canada a new voice <http://www.geocities.com/SoHo/Village/6263/> ------------------------------------------------------------