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kathrynsaupp wrote: > I take a 50/200 CR at 7am and 7pm.... 3 doses of regular 6.12.4. > .... comfortable movement until 3pm then must struggle .... until > around 8:30-9pm when the evening CR hits..... Why should you be given a schedule that produces "off" periods? This makes no sense to me. Also, I don't understand why the 4:00 p.m. does nothing. What is the strength of the regular dose? What do you take it with? If your puzzling ration of pills was all I had to work with until my next physician appointment (and I would make sure it was with someone who understands PD and PD meds), then, given my own med requirements, I might try something like this as a baseline schedule and proceed from there to fine tune, recording doses, times and results in a log as tuning progressed: 6:30 a.m. Two-thirds of a regular (assuming strength is 25/100) 8:00 CR noon Two-thirds of a regular 1:00 p.m. CR 4:30 1 whole a regular 7:00 Two-thirds of a regular Roughly speaking, compared to regular Sinemet, it takes a CR about twice as long to kick in, and the CR lasts about twice as long. See http://www.rxmed.com, click on "Prescription Information", "S", and "Sinemet CR". > I had [hate?] to complain but. . . Why remain in discomfort if it isn't necessary? Best wishes, Phil Tompkins Hoboken NJ age 61/dx 1990