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Sandie, I can answer your question with my relatively limited knowledge about neural biochemistry and neural transmitters as a clinical psxychologisr. The apparent connection between schizophrenia and PD is the class of drugs which was the first to successfully treat schiz.--the phenothiazxines,.like thorazine and merllaril--often caused Parkinsonian symptoms--such as shuffling gait, fixed, mask-like facial appearance and drooling. That, plus the fact that PD meds--especially sinemet--can cause some people to hallucinate and have other psychotic symptoms led some to conclude that PD and schiz. are biochemically opposite to each other. Further when some of the anti-psychotic drugs were used to treat PD-related psychoses, they made the PD symptoms worse. So, there appears to be some kind of inverse relation between PD and schiz but this appears to be moretof theoretical than practical value at this time, and the relationship is not fully understood. And, fortunately, a new class of anti-psychotics has been discovered in recent years which effectively treats schiz without causing Parkinsonian side effects and which has treated and revived some of the most intractable, withdrawn schiz's who had been resistant to all other anti-psychoticc drugs. The major, most widely used of this class of drugs is clozapine, brand name clozaril, and the only major downside thus far is that it can causea potentially fatal blood disorder known as agranular cytosis.but this cab be easily monitored by required, weekly blood tests. Lo and behold, clozaril ws also found to be effective in treating PD-related psychotic symptoms without causing a worsening of PD symptoms; in fact, in some cases, improvement ioin PD symptoms was noted. The dosage of clozaril use to treat PD-related psychosis is minuscule, compared to the level needed to treat schiz., spo the risk of agranular cytosis. I probably covered 'everything you ever wanted to know about schiz and PD--and a few things you didn't want to know, but I hope this helps to answer some of your Q's. Marty Polonsky