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Jennifer and the million other PWP's who crave sweets--not to mention ICE CREAM - did I say that? --: Could a single GENE, if mutated, shut down the dopamine to adrenaline pathway, and cause a variety of different diseases, including PD or diabetes? Could this explain why there seem to be many more diabetics within the families of PWP's than usual? Are any of the PD foundations and societies, American or overseas, looking into this? Robin Elliot, Carole Cassidy, Ida Kamphuis, Brian Collins, Perry Cohen, Parkinson's Alliance, NPF, APDA, other countries--what do you think? Any biochemists or geneticists out there wish to respond? Thank you, Ivan On Fri, 7 May 1999 17:06:06 -0400 Jennifer Smith <[log in to unmask]> writes: I plan to pass the info >onto my>friend who asked me the question about sugar cravings and PD. >Jennifer Smith > >Ivan M Suzman wrote: > >> ^^^^^^ WARM GREETINGS FROM ^^^^^^^^^^^^ :-) >> Ivan Suzman 49/39/36 [log in to unmask] :-) >> Portland, Maine land of lighthouses 64 deg. F :-) >> ******************************************************************** >> Hello again, folks, >> >> Here's a thought, ESPECIALLY if you have discovered that you need >extra >> SUGAR at times: >> >> PD is caused by lowered dopamine. Dopamine breaks down to >adrenaline; >> so I wonder if dopamine deficiency in PWP's means lowered adrenaline >in >> those PWP's, too. >> >> Adrenaline, meanwhile, inhibits insulin. So, I also wonder if >lowered >> adrenaline could leave insulin production less regulated, resulting >in >> excessive insulin in PWP's. >> >> Raised insulin lowers blood sugar. Could this explain a PWP's >need for >> sugary foods and sweets, which we often talk about here on this >list, to >> compensate? >> >> "Hypoglycemia" is low blood sugar. A neurologist I talked to says >that >> lowered blood sugar symptoms--shaking muscles, cold sweat, >exhaustion, >> tremor -- are very similar to lowered dopamine symptoms that appear >> either before dose, or with end of dose off-periods of PWP's . >> >> One last thought for now --does lowered adrenaline give you that >BLAH >> feeling (no motiviation to do anything because you just DON'T have >the >> energy?