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My mother Joyce (69) was on Rilutek for only a few months -- she couldn't tolerate it. I think it made her feel confused and tired. (She's taking other drugs, so it may have been the mix). Anyway, she's off it now. It was given to her after she was rediagnosed with a Parkinson's Plus disease (striatonigral degeneration). Her doctor told me that it helps slow the progress of the disease some. Wish she could have stuck with it. Debbie White [log in to unmask]