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Ed , There is no prohibition for using entacapone and CR for most people. I was asked not to use CR because "do not use CR" was a part of the drug testing protocol. Will ---------- From: Steve Rumley <[log in to unmask]> To: [log in to unmask] Subject: Re: entacapone Date: Wednesday, May 12, 1999 10:25 AM Have I misunderstood, or did Will Johnson indicate that Entacapone should not be taken with Sinamet CR or Madopar CR? If it shouldn't, why is that? Ed Rumley, CG for Jack 63/dx56