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Hi Steve! I was told - by an informations person at the Swedish state chain of pharmacies - that Entacapone is effective for approximately 30 minutes(!) after taking it. So, it's not lasting anywere near as long as the Madopar CR... No danger in taking it, but it is no great help after a while. /John (30/28/18) >From: Steve Rumley <[log in to unmask]> > >Have I misunderstood, or did Will Johnson indicate that Entacapone >should not be taken with Sinamet CR or Madopar CR? If it shouldn't, why >is that? > >Ed Rumley, CG for Jack 63/dx56