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In a message dated 5/22/99 6:05:34 PM Central Daylight Time, [log in to unmask] writes: << Today we decided to give her Sinemet every 2.5 hours so that she can eat a little bit more during her meals. She did not do as well as the previous two days but she is still much better than before the surgery. We will probably go back to dosing every 2 hours. As for any other medications. She is taking Elavil 30 minutes before bed and Restoril right before going to sleep. A few weeks ago she tried a very low dose of Permax but she nearly passed out. We are going to wait for her to recover from the surgery and gain a little more weight before trying the Permax, again. >> Teresa, I don't know this to be true, but it seems to work for me (usually-nothing ever works well constantly with this stupid disease).: 1 Because of the reaction you mentioned before, I think I would suggest Mirapex to the neuro. It doesn't act like an ergot. 2. Try a little protein in her diet during the day. While it still reduces the power and duration of Sinemet, I have found it useful in smoothing out the peaks and valleys. The proper time to try it is about 45 minutes after the last (previous) Sinemet dose. Because I too am often hungry, I have to use care to not go overboard. However, working up slowly, I have discovered I can get away with the occasional daytime big Mac. Regards, WHH 55/38/37 PS: My last palli was in '94