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Retinoic acids, regulate the expression of the dopamine receptor D2R. D2R-knockout mice lack these retinoic acid receptors and exhibit Parkinson's disease. "Vitamin A functions in the regulation of the dopaminergic system in the brain and pituitary gland by Wolf G" on Pub Med Nutr Rev 1998 PMID: 600825, RAR-related orphan receptor A, Receptors for retinoids so named because their ligands are unknown. The alpha 1 and 2 isoform binds to hormone response elements, but have differend specificities. The alpha 2 is located on the minus strand of a cytochrome c-processed pseudogene. ( cytochrome c = #602413 Complex II or NADH-Ubiquinone, in the mitochondria has 4 subunits, the flavoprotein 600857, the iron-sulfur protein 185470, and 2 intregral membrane proteins: the large cytochrome b SDHC or Succinate dehydrogenase subunit C or subunit D.) ( Succinate I believe is in paint thinners and herbicides effect the flavoprotein FAD.) ( Acetylcholine makes you tremor and succinylcholine makes you relax.) (CREB is cAMP or cyclic AMP response element. cAMP is overproduced in Parkinsons.) PMID: 601972, RAR-related orphan receptor B, PMID: 602943 RAR-related orphan receptor C, and PMID 180245 Retinoid X Receptor, alpha is distal to the dopamine beta-hydroxylase gene 223360. PMID 124010. Cytochrome P450 is responsible for the metabolism of about 60% of all clinically used drugs, including barbituates and psych drugs. Low P450 is related to Parkinsonism. PMID 602239 Cytochrome P450 metabolizes retinoic acid. Perhaps Parkinsons and Schizophrenia are both effected by retinoic acid levels. PMID 303800 Color Blindness. Thanks for the survey. About ten people responded they had Parkinsons and were colorblind. Yes color blindness is quite prevalent. PMID 300100 ALD is a disease, a neuro disease in which color blindness is a factor. It is a disease about degeneration of the myelin sheath made out of apolipoprotein. Pub Med "The apolipoprotein E in Parkinson's disease with Alzheimer lesions". This is only one type of Parkinsons disease. But if you are color blind, I'd be interested in retinoic acids and orphan neurons. Thanks for listening. [log in to unmask]