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I can't offer firsthand advice to Jennifer and others, but here are a couple of library refs from a few years ago, that might interest your neurologist(s). Cheers, Joe Giladi, N: Neur 1995;45:1028 Cyclic menstrual hormone changes profoundly affect PD symptoms and amount of medication needed. Factor, S: Movement Disorders 1993;8:240-241: Acetazolamide (Diamox), used to prevent and treat acute mountain sickness, dramatically reduced menstrual-related fluctuations of PD symptoms. Formal trial is urged. -- J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks, CA 91403-5013