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Just wanted to add how we dealt with this lousy situation. After suffering thru this PMS balancing act for years we proposed to Nancy's GP, Neurologist and gynecologist a test that was deemed to be safe by all and worth a try. The botttom line was Nancy was put on a birth control pill called loestrin without interuption. That is she did not take the inert pill for one week each month but instead took the real pill all month long. this meant no menstration. The results were immediate and continued until menopause. There were no more radical swings in emotions and the daily parkinson's meds could be trusted to deliver their normal benefit. I say normal benefit because there are still other factors like protien intake that effect the degree of benefit. This contiuned until she reached menopause. Now she takes prempro which is an estrogen supplement. With what we know now she would have used this method to manage her PD much earlier in life. Hope this helps. The Martones -----Original Message----- To: [log in to unmask] Subject: Re: PMS and PD Don't Mix!!!! Jennifer, I'm with you only in what is called perimenopause, that gray area when the female reproductive system is doing all sorts of adjusting. Trying to adjust the PD meds and the hormones has had me in tears, too! When I complain to my male neuro and primary care dr. I don't feel the empathy I need. At least both have allowed me to try readjustments on hormones/pd meds and I'm hoping to see improvements. It's not all in our minds!!! Jeanette Fuhr 48/47/44?