Brian, You wrote, > Hello Terry, You were the only one to pick up my rather provocative statement. > I did'nt really expect to get away un-noticed. You didn't go un-noticed - just unremarked upon <grin>. I must say I'm intrigued by your contention that an excess of levodopa actually serves to shut down the natural dopamine system. If this is the case I would think that a direct correlation could be drawn between size of dose first prescribed and speed of progression of the disease. I would imagine that there is a vast amount of uncollected evidence relating to this, just waiting for some candidate for a masters degree to collect and collate it. Dennis +++++++++++++++++++++++++++ Dennis Greene 49/dx 37/ onset 32 There's nothing wrong with me that a cure for PD won't fix! [log in to unmask] http://members.networx.net.au/~dennisg/ +++++++++++++++++++++++++++