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hello Kathy, I am also 52, recently diagnosed and suffering from what I believe to be PD related depression. As I was titrating up on Zoloft in january, I noticed my PD symptoms were getting worse so I stopped it, told my doc and waited about 3 weeks for it to leave my system. I am not taking an antidepressant now. I don't know if it was me, or my Mirapex that caused the conflict, but watchout for Zoloft conflicts, tell us what your PD meds are and welcome to the list. Gary 52/51/4?