Hello Kathy I have used Zoloft for the past 4 years and no problems. I am sure it is not for everyone. My Neuro told me it was a very tollerable med for most people. Don't get discouraged if it doesn't work. There are lots of med and combos of meds that will in the end work for you. Up to 9 Sinimet 25/100 per day seems excessive to me. Do you get any diskenisia ? (uncommanded movement....like jerking ?) That is caused by to much Sinimet. 25/100 is a low dose of Sinimet. maybe you could talk to your DR about Sinimet CR. It is a controled release version of regular sinimet. I take 50'/200 Sinimet CR 3X per day and supplement it with either 1/2 or whole tab of Sinimet 25/100 when there is stress from work or I am doing excessive physical things like yard work. CR helps with the off times and the roller coaster ride you sometimes get from regular Sinimet. My point is as always ...Hang in there it will work out for you. Frustration and stress are our worst enemies Terry