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Hi Jane, People who have MSA often don't respond to Sinemet. Your father's response to Sinemet and diarrhea apears to suggest that he is in this category.Has he been evaluated and tested for MSA by an MSA specialist?Have you joined the Shy-Drager e-mail list?You can learn alot about MSA there. Your father's lack of bladder and bowel control is typical of Shy-Drager/MSA syndrome. By the way,Sinemet usually causes constipation,not diarrhea; another suggestion that Sinemet is not for him. Good luck. Gil,CG for Aliza dx PD 2/95,dx MSA 10/98 ----------- You wrote: Date: Tue, 15 Jun 1999 12:19:28 -0400 From: Jane Koenig <[log in to unmask]> Subject: Stomaching Sinemet Hi Listfolk, My father, Fred (80), has been diagnosed with Parkinsonism (maybe MSA, no real clear diagnosis) for a little less than two years. Two doctors have tried Sinemet (25/100) on him, starting with 3 whole pills a day. In each instance he suffered with diarhhea and, seeing no improvement in his condition, gave it up. The 2nd of these doctors wanted to titrate him up to a higher dose, but Dad couldn't handle it. He has also tried every other agonist out there, except Tasmar. Most had some sort of negative effect. He would now like to try Sinemet again. I cut some pills in half and he started with 2 halves a day, 'after' eating breakfast and lunch. At the end of the second day he had a bad evening and night, suffering with both bladder and bowel control. Since he is now wheelchair bound and stuck in bed all night until his morning health aid shows up, this was quite unpleasant for him. Can anyone provide some insight on how to acclimate his very sensitive system to Sinemet so he can build up to a large enough dosage to determine if it will do any good for him? Thanks, Jane Koenig (daughter of Fred, 80/2ish)