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Hi Gilles, Welcome to the group and unfortunately to the PWP fraternity as well. I presume, but obviously cannot be certain. With your recent diagnosis that low dose may be helpful then again it may not be. I likely would be suggesting an agonist rather than Sinemet especially after the diagnosis is made firmly, but you doctor may have his reasons for starting the Sinemet. If your doctor is not a movement disorder specialist (as opposed to a general neurologist of family practitioner) I would suggest at least consulting with one. (I always suggest this since it is difficult for a generalist to keep up with the advances in PD research.). Sorry I can't be more definite at this point. Charlie "Cloutier, Gilles" wrote: > Dear Dr. Meyer: > > I am writing to you (and have copied the list) because you are very > knowledgable and have been most helpful to many members of the list. I have > recently been diagnosed with PD by a neurologist but something doesn't seem > right. > > I have been prescribed 2x100mg of Amantadine (since January) and this seems > to help me move better and I no longer have heavy-duty headaches at the back > of my head near the base of my skull. This is good. However, since mid-may > I also am taking 1/2 Sinemet 100/10 twice a day but this doesn't seem to be > doing anything. It was supposed to help me regain the use of my right hand > but so far not so good. > > Do you (or anyone) have any idea what might be causing the Sinemet to have > no noticeable effect. The neurologist assigned to me said it could take a > couple of weeks before the Sinemet does anything, but it's been longer than > that and still no results. He also told me not to increase the dosage > (why?). I'm curious about what to expect the drug to do, does it restore > mobility fully or partially for a while, it there a minimum required dose to > do anything at all. > > Anyway, if you or anyone can help, I'd like to hear from you. > > Personal details: 41yrs old, male, diagnosed 1999, problems since 1992 > > Gilles Cloutier > [log in to unmask] -- ****************************************************************************************** Charles T. Meyer, M.D. Middleton (Madison), Wisconsin [log in to unmask] ******************************************************************************************