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Bruce, Because of the seriousness of the diagnosis or lack thereof I want to qualify my statement a bit. If there is no sinemet response and the PET scan is negative in terms of no decreased activity and a sinemet response is also not present, then PD is highly unlikely. If either is positive then I would say that it is equivocal. I don't know whether the diagnosis of PD is "officially" sanctioned in this way- I will check- but I think the chance is quit small that the diagnosis of PD could be made in the absence of both of these parameters. Charlie "B. BRUCE ANDERSON" wrote: > Thank you, Charlie. I had no idea that the PET scan was that definitive - > i'd surely have had one years ago if i had known. -- ****************************************************************************************** Charles T. Meyer, M.D. Middleton (Madison), Wisconsin [log in to unmask] ******************************************************************************************