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Helen, I recommend that you simply stay on your regular schedule of meds the first day of travel. The easiest way to do this is to keep your watch (or a watch or any timepiece) on your original, home time and follow your regular med schedule in your usual time zone. If you travel in a direction in which you lose time, you may end up taking additional dose(s) but that will be necessary only this 1 day. This would apply to your return trip But you will be traveling in the opposite direction and you will gain time, so you may end up taking 1 or more less doses. Anyway, assuming that you don't take meds while you sleep, the next morning, I would simply reset all of my timepieces to the new, local time zone and then run my usual schedule according to the new, local clock. If you are usually very regular in following your med. schedule, it may take your body a day or so to adjust to the "new" schedule--just like it usually take a day or so to adjust to "jet lag." Good luck and bon voyage!.