http://biz.yahoo.com/bw/990614/ca_ligand__1.html Mutant RXR cause Parkinson locomotion. Retinoics cause birth defects like blue-yellow colorblindness in Parkinsons and unusual olfactory dysfunction in Parkinsons CREB is cyclic amp response element, a retinoic acid, that is responsible in genetic disorders dealing with dopamine receptors and also is involved in cancer. T-cells are elevated in Parkinsons, causing IgG to substitute for insulin receptors causing insulin-resistant type two diabetes. Glutathione dependent leukotrienes are low in Parkinsons. Leukotrienes are involved in psoriasis. Targretin is for cancer, type two diabetes, and psoriasis. Company also has other retinoids for RAR receptors, one of which effects cytochrome c, of the complex I NADH-CoQ10. Company also has STAT drugs that activate transcription factor, like stem cell stimulation. Company is not doing any research with Parkinsons. [log in to unmask]