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Hi Clare.... Originally, as I began adding vitamin E to my daily pill-regimen I asked the pharmacist at Kaiser (my HMO) for a recommendation on what would be an appropriate daily dose since at that time I hadn't a clue. Generally, up until my recent surgery (one month ago) I'd maintianed my daily intake of Vitamin E at around 1200 to 1600 ICUs daily. HOWEVER, two weeks prior to the surgery, the surgeon had me go off ALL supplaments and vitimans except for one multi-vitamin/mineral tabled daily. That meant going off the vitamin E, and the Gingko Biloba abd Coenzyme CQ10 with made up my daily supplaments. The surgeon explained to me that those over-the-counter supplaments are known to slow down blood clotting time and is potentially very dangeous because of that. Based upon the above, when I added vitamin E back into my daily regamin I put a ceiling on the amont I'd take each day - settling at 800 ICUs a day. The problem with OTC suppliments is that neither doctors or pharmacist seems to have a uniform opinion on what is a safe level of the daily amount of suplpmemts, and goodness only knows how the vast majority of us decide what OTC supplaments and daily to take SOOO...my answer to your original question is that I'm "winging it." And what works for ME is what I take, and I believe everone should base their own suppliment intake after doing extensive personal research so that they won't overdo it and experience negative side effects. Barb Mallut [log in to unmask] --Original Message----- From: Clare Wilson <[log in to unmask]> To: [log in to unmask] <[log in to unmask]> Date: Friday, June 25, 1999 2:29 AM Subject: Re: Use of Vit.E for Leg Cramps >Hi Barb. I'm having what is no doubt dystonia and >furthermore, the painful cramp leaves muscle soreness >now going into the 3rd day which makes walking >even more difficult. In reading the archives, your >post on the subject suggests 2000 IU Vit. E. >From my nursing days, I recall Vit.E is a fat >soluble vitamin. Isn't there danger of >build-up with that dosage? I've taken 400 IU daily >for years, but obviously need some additional >help now. Am looking for your words of wisdom >here, to see if you still feel that advice is still valid. >Thanks friend. > >Clare Wilson >