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Hi Suzanne.... M'dear... for MOST of us with Parkinson's, Sinemet does it's "thing" for several years with few, if any, side effects. Not only that, it generally WORKS, so with the commencement of the drug, you'll reach a comfort level you most likely haven't felt for some time. If you begin taking the Sinemet over the weekend, IF you experience any side effects (I had a 4 day period of mild nausea immediately after beginning the 25/100 tablets) they prolly won't interfere with your job. By the way, after taking the 25/100's for 3 months with absolutely NO change in the PD symptoms, I asked my then neuro for a stronger pill. He hemmed and hawed a bit and let me know HE thought that if I WANTED the 25/100's to work, they WOULD (Well, POOH on HIM! I gotta 'nother neuro! SO THERE, Doc!) I got the prescription filled for the higher dose of Sinemet, said a little prayer. and popped a HALF of a tablet (starting out cautiously), taking another half tablet about 4 hours later in the late afternoon. Expecting the higher dose would work immediatly, I was surprised to find no change in my conditon (actually, 'surprised" is not the right word!) <grin>. I continued taking the half 25/250, and WHOA - within a few days there WAS a change - a VERY positive change. Sooo... I suggest ya bite the bullet and start the Sinemet. I suspect you'll find yourself happy that you did. An remember, we're all here rooting for ya. YOU GO GIRL! Barb Mallut [log in to unmask] ---Original Message----- From: Suzanne M Weiler <[log in to unmask]> To: [log in to unmask] <[log in to unmask]> Date: Wednesday, June 23, 1999 11:13 AM Subject: so scared of sinimet >dear list, > > my name is sue and i have been lurking here almost since my diagnosis > >last december. i am 51 yrs old. i just had my second visit with my neuro last > >thursday. he thinks its time for sinimet. he has prescribed 25/100--one tablet > >in the am for one week, then one tablet twice a day thereafter. > > i filled the prescription and it has been sitting on my kitchen >counter next > >to my vitamins and hormones for a whole week. i guess i need some hand > >holding. how do you start taking something that (in spite of being the gold > >standard) is apt to cause all kinds of nasty side effects? > > i work full time in a gift shop where my tremor is affecting my fine >motor > >skills. there has been marked progression in the last year. > > you guys give great advice, and it's always given with such love and > >concern. i know you understand how i feel. so i'm hopping you'll be > >able to give me the kick in the pants i need to get started. >