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My experience with sinemet was ... after the surgery I didn't need it any longer. Quit taking it. I actually feel better without it. Now I would like to get off Mirapex. >Dear Charles, >I noted you were on ropinerole which I understand will not be marketed >here.(Australia) I am at present titrating Mirapex which is just becoming >available here. It appears the latest edition of Brain has confirmed that >chronic stimulation of the subthalamic nucleus and levodopa produce >dystonia. Something I was pretty well was aware of through personal >experience and my visit to Professors Benabid and Pollack. I have not been >able to try and get rid of my Levodopa as none of the ergot agonists worked >for me. If its not an imposition could you tell me how long was your >titration period and if you were on ropinirole before your DBS. I am >currently working my way up by increasing my Mirapex by 0.25, 3 times a day >every five days and yesterday (Sunday) I actually had no levodopa on a dose >of 3/4 of a milligram of Mirapex three times a day. As I'm working and >driving today I had to take a very minimal dose of levodopa this morning The >results so far are stunning and certainly compliment the DBS surgery. At >last. > >Kind regards >Peter Dawkins jjjane http://www.geocities.com/soho/village/6263/pienet/people/hithross.html