Irene: Just for some more info for your friend - based on my husband's experience. I notice the protocol has mentioned the Bisacodyl l0 mg. suppositorites but there is also a 5mg. enteric coated pill available (same as Dulcolax) but Fleet has a generic available over the counter which has worked for him several years and only cost half as much as Dulcolax. He used to have chronic constipation before the PD hit him and since he's been on Cogentin from the beginning (l3yr ago) he did have severe impactions for some time, trying all the usual remedies before he was told about the Bisacodyl. He uses it regularly, but only as he feels he needs it. As noted constipation solutions are as varied as the individuals, but in case your friend hasn't run across this possibility I thought I'd pass along the info... By the way, my husband hasn't had any severe episodes of impactions for over 5 yr now - hope your friend finds such a good remedy for her - impactions are definitely big trouble and can even be scary - since the medical community doesn't seem to act like it's too "big a deal". The pain can be awful and time critical - so hope she finds a satisfactory regimen soon! Marie