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Sue - If you have nausea when you begin taking Sinenet ask your PD specialist about LODOSYN which is manufactured by Merck as is Sinemet. I found that you don't have to stay on LODOSYN more than a few weeks or less while you build up your Sinemet. Start the Sinemet with 1/2 tablet of the yellow 25/100 tablet and 1/2 LODOSYN. After a few days increase the SInemet to one tablet and use one LODOSYN. As you build up you can begin immediately to cut back of the LODOSYN. Important to coordinate this under your doctor's guidance. But this what worked for me. I am 82 and am three years with Sinemet. I walk with vigor. My shoulders are back and my head is high and I can do lunges, squats, run, dance the hora, you name it, I do not shuffle. People say they can't see anything wrong with me. If the Sinemet causes a problem I"ll find a way to change with my doctor's help. You can get immediate relief from the Sinemet. Good luck. Robert Friou Suzanne M Weiler wrote: > dear list, > > my name is sue and i have been lurking here almost since my diagnosis > > last december. i am 51 yrs old. i just had my second visit with my neuro last > > thursday. he thinks its time for sinimet. he has prescribed 25/100--one tablet > > in the am for one week, then one tablet twice a day thereafter. > > i filled the prescription and it has been sitting on my kitchen > counter next > > to my vitamins and hormones for a whole week. i guess i need some hand > > holding. how do you start taking something that (in spite of being the gold > > standard) is apt to cause all kinds of nasty side effects? > > i work full time in a gift shop where my tremor is affecting my fine > motor > > skills. there has been marked progression in the last year. > > you guys give great advice, and it's always given with such love and > > concern. i know you understand how i feel. so i'm hopping you'll be > > able to give me the kick in the pants i need to get started.