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Janet, Fatique is a major symtom, why do I think that will change? 17 years! Eek! In five years I'm showing the down side of this disease in all its glory (there is an up side??) You didn't mention constipation, or didn't you want to. Horay for prunes and Bran flakes-I suppose that doesn't work after awhile too. What do you do for depression? I am naturally drawn to tears when I think how hopeless this all is, yes I try to think positively & am thankful for what I do have, but get over-whelmed by the nastiness of it all in my fumbling moments of previously easy tasks. Sincerely, Patricia 62/5 years Sinemet CR, Permax, Zoloft, HRT