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Patricia, You might consider asking your neuro about the feasibility of using either NADH or Co-Q10. Credible studies on both these supplements are underway at Parkinson research centers. One neuro I work with recommends Co-Q10 to a number of his patients. Fatigue may be due to a number of different conditions, so what works for one person may not be at all helpful for another. Your neuro should have an idea of what might work best for you. For constipation, it's very important to get plenty of water -- people with PD are frequently in a state of chronic mild dehydration, which contributes to constipation, as well as many other conditions. Fiber is also important, as it both assists in keeping the stools bulky and protects against colorectal cancer (risk for this cancer is increased with chronic constipation). Prunes contain a mild laxative, usually one or two servings of prunes or prune juice are enough. Best regards, Kathrynne [log in to unmask] wrote: > > Janet, > Fatique is a major symtom, why do I think that will change? 17 years! > Eek! In five years I'm showing the down side of this disease in all its > glory (there is an up side??) > You didn't mention constipation, or didn't you want to. Horay for prunes and > Bran flakes-I suppose that doesn't work after awhile too. > What do you do for depression? I am naturally drawn to tears when I think > how hopeless this all is, yes I try to think positively & am thankful for > what I do have, but get over-whelmed by the nastiness of it all in my > fumbling moments of previously easy tasks. > > Sincerely, > > Patricia > 62/5 years > Sinemet CR, Permax, Zoloft, HRT -- Kathrynne Holden, MS, RD Medical nutrition therapy Author: "Eat well, stay well with Parkinson's disease" "Parkinson's disease: assessing and managing unique nutrition needs" http://www.nutritionucanlivewith.com/