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http://biz.yahoo.com/bw/990623/ca_ligand__1.html Targretin activates Retinoid X, mutant retinoid X mice have parkinsonian locomotio. CREB, cis response element for cAMP, is a retinoic. CREB regulates TCL4, T-cells of lymphoma and CREB regulates proenkephalen, enkephalin is of the D2 dopamine receptors Pertussis effects adenyl cyclase and overproduces cAMP and Parkinsons often develops later in life. Gamma-T-cells are high in Parkinsons. Beta-2-microglobulin is replaced by the insulin receptor when it associates with a MHC class 1 Heavy Chain causing insulin resistance and type two diabetes. Lipids are a class 1 protein and Parkinsons is a problem of lipids. Targretin is for type two diabetes too. Arachidonic Acid is an all-cis retinoic structure that governs the leukotrienes that govern natural cis fats like omega 3 oil used for psoriasis. Targretin is being tried for psoriasis. Retinoics cause birth defects, especially facial defects. Parkinsonians have a smell defect, so unique that a test has been made that will tell what relatives will get parkinsons. Parkinsons are more frequently color-blind, especially blue-yellow, or blue green. No one is trying targretin for Parkinsons, the company does not plan to market it for parkinsons. No one is researching it for this disease. I asked NIH if there were anyone studying retinoids and Parkinsons and was told many scientists are researching Parkinsons, but not who is studying retinoids. I think there is some kind of connection here. Once again, my husband had Parkinsons, diabetes type two, and psoriasis. And his twin, has another retinoic disease, breast cancer. Targretin is for breast cancer. [log in to unmask]