Just wanted to share my personal experience re:meds. Tried janet's hint about letting the SinemetCR melt in your mouth (I know you're not supposed to-I'm a nurse), but, you know, it really seemed to help. I don't know if it was psychological or what but I am going to try it for a while. Re: Permax-my neurologist is in love with the drug-I've been taking it for about a year and a half, to smooth out the times between the Sinemet doses, and while its o.k., I'm not crazy about it. When we try to increase the dosage I find I get peripheral edema and the med in general makes me a bit antsy. Incidentally, I sometimes melt the Permax in my mouth, too. Well, that's my 5cents worth, Carole Hercun _________________________________________________________ Do You Yahoo!? Get your free @yahoo.com address at http://mail.yahoo.com