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I had been taking 3/4 10/100 reg. Sinemet every 2 hrs., with added 1/2 Sinemet CR at bedtime. I then increased all this to 1 tablet every 2 hrs, & 3/4 CR at bedtime. This seems to now meet my needs. Perhaps my needs increased because of the increased stress due to my husband's cancer recurring & becoming incurable. As a general question, does increasing Sinemet more quickly increase the need for future increases? I don't know how to ask this question; something like "priming the pump". M.Dawn