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---------- > From: Sharon & Jim LeBlanc <[log in to unmask]> > To: [log in to unmask] > Subject: Second References forTheory of Environmental Parkinsons- Pollutant Botulism - Clostridium Botulinum > Date: Monday, July 05, 1999 1:36 PM > > 8. PMID 124040 - Cytochrome P450 (metabolizes retinoic acid) - Full-length > cDNA genomic clone found to code for N-nitrosodimethylamine demethylase > activity. > 9. PMID 9050783 - Disruption of local retinoid-mediated gene expression > accompanies abnormal development in the mammalian olfactory pathway. > 10. Retinoid regulation of transglutaminase gene expression by Peter Davies > - CRISP RRE1 and HR-1 inhibit transglutaminase (Inhibition of Huntingtin > may be a great treatment of Huntingtons Disease) > 11. PMID 602049 - RAS-Related C3 Botulinum Toxin (BOTOX) substrate RAC2 > displayed relative myeloid tissue selectivity. RAC1 and RAC2 are substrates > for ADP-ribosylation by C3 component of botulinum toxin. (ADP= adenosine > diphosphate) > 12. PMID 9252344 - Characterization of RAC3, a novel member of the RHO > family - Rac1 and Rac2 are critically important in regulating multiple > signal transduction pathways in eukaroytic cells. RAC3 is an active GTPase, > and this activity is regulated by Bcr (breakpoint cluster) > 13. PMID 151410 Breakpoint Cluster region; Bcr.- Chronic myeloid leukemia > is fundamentally a genetic disorder, specifically a somatic cell genetic > disorder which has environmental causes shuch as irradiation and chemical. > 14. PMID 180240 Retinoic Acid Receptor, Alpha, RARA - Acute promyelocytic > leukemia (APL) the breakpoints in 10 APL cases examined were shown to > cluster in the 12-kb region of chromosome 17. See Wells 1997 and NUMA1 for > discussion of a RAR/NUMA1 fusion protein associated with APL. > 15. PMID 602124 Dystonia 7, Torsion; DYT7 - Typical spasmodic dysphonia and > responded with botulinum toxin. (Clostridium botulinum is anaerobic, lives > without oxygen, forms nitrite, clostridium bryzantii is involved with the > oxidation of fatty acids. BOTOX prevents the release of chemical > transmitters that activate muscles, and inhibits Acetylcholine) (BOTOX = > shot of Parkinsons). (I think tremors are the muscles fighting the > inhibition of acetylcholine, eventually they become rigid and painful, then > don't work at all.) > 16. PMID 9733726 Inhibition of ribonuclease P by retinoids. All retinoids > behave a classical competitive inhibitors. > 17. PMID 9405615 Regulation of dopaminergic pathways by retinoids: > activation of the D2 receptor promoter by members of the retinoic acid > receptor-retinoid X receptor family. > 18.PMID 9452386 Impaired locomotion and doamine signaling in retinoid > receptor mutant mice > [log in to unmask]