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---------- > From: Sharon & Jim LeBlanc <[log in to unmask]> > To: [log in to unmask] > Subject: Third References for Theory of Environmental Parkinsons - Pollutant Botulism - Clostridium Botulinum > Date: Monday, July 05, 1999 2:40 PM > > 19. PMID 123810 Cyclic AMP response element - binding protein CREB1 - > Stimulates transcription of an array of cAMP (Adenosine Monophosphate) such > as proenkephalin and FOS. CREB1 may be identical to activating > transcription factor (ATF). Taylor mapped CREB1 to 2Q34,3-Q34 and > speculated the possible involvement in genetic disorders or cancer, pointed > to the fact that TCL4, a locus implicated in T-cell leukemia/lymphoma is > located 2q34. (Proenkephalin - enkephalin- D2 dopamine receptors). > 20. Ligand Pharmaceuticals - 1999 - LGD1069 - Recently, 9-cis-retinoic > acid, a high affinity ligand for retinoic acid receptors and retinoid > X-receptors (RXR) was shown to have efficacy superior to all-trans retinoic > acid as a chemopreventive agent in the N-Nitroso-N-methylurea induced rat > mammary carcinoma. (Breast Cancer). Cutaneous T-cell lymphoma (CTCL). > (Targretin capsules are under orphan drug designation.) > 21. PMID 600825 RAR-Related orphan receptor ALPHA, Retinoic Acid-Binding > receptor ALPHA (Alpha,Beta,Gamma) > 22. PMID 9884583 Vitamin A functions in the regulation of the dopaminergic > system in the brain and pituitary gland - D2R knockout mice lack these > retinoic acid receptors and exhibit a defect in locomotion similar to that > seen in Parkinsons disease. > 22. C/EBPE - Study of a novel Myeloid Transcription Factor by Koeffler, > Philip H. - C/EBP, a CCAAT enhancer binding protein that is a frequent > partner of CREB2. It is a human myeloperoxidase promoter. (Parkinsons is an > overproduction of lipid peroxidation. PARK 1,2,3 Parkinsons genes, alpha > synuclein, produce too much threonine that increases lipids and lipid > peroxidation into the brain. It is similar to Huntingtons disease that > introduces too much glutamine into the brain. Glutamine binds with > Huntingtin, a transglutaminase , that is effected by CCAAT- or CUTL1 or > Caspase-1 that cuts the huntingtin protein making globs that cause > Huntingtons brain cells to die.) > 23. PMID 180220 Retinoic Acid Receptor , BETA, RARB - HAP (HBV-activated > protein) is a retinoic acid receptor. (HAP1 binds with Huntingtin. HIP2 or > Huntingtin-associated protein binds with HAP1which binds with dynactin P50 > and dynactin P150 that binds to centractin, and F-actin . HIP-2 or E2-25K > or ubiquitin-conjugating enzyme is part of Complex I, NADH-Ubiquinone > (CoQ10)). > 24. PMID 9932947 -AAT Alpha-1-gene mutation Alzheimers Disease. AAT > overrepresentation in Parkinsons disease. AAT and Transglutaminase bind > with prealbumin found in amyloid fibers of Alzheimers (Maybe Lewy Body > Parkinsons) > 25. PMID 180231Retinoic acid-binding protein CRAB2 linked to muscle > nicotinic acetylcholine receptor alpha-chain (Acra) and catalase-1 (CAS-1). > 26. Transcriptional regulation of cell growth. by Verma, Inder M. - CRISP - > Retinoids repress transcription by early response genes like Fos, Jun, and > NF-KappaB/Rel. Control of cellular proliferation by cAMP. > (Pertussis-Parkinsons) (ethyl-carbamate) > [log in to unmask]