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---------- > From: Sharon & Jim LeBlanc <[log in to unmask]> > To: [log in to unmask] > Subject: Fourth References for Theory of Environmental Parkinsons - Pollutant Botulism - Clostridium Bodulinum > Date: Monday, July 05, 1999 3:21 PM > > 27. Biology and Pathology of a modulator of FGF by Wellstein, Anton - CRISP > - fibroblast growth facto (Stem Cells) is mobilized by binding to a > secreted binding protein for FGF(BP). Retinoids downregulate BP mRNA. (Why > stem cell stimulation and GDNF or glial-derived growth factor works for > Parkinsons) > 28. RXR/PPAR regulated expression in adipocytes by Ahuja, Harleen S. - > CRISP - RXR-specific ligand can produce an acute effect in 3T3-L1 > differentiated adipocytes. (APOE4 apoprotein, apolipoprotein genetic > Parkinsons). > 29. Journal of Neurochemistry - Nicotine prevents experimental Parkinsons > in rodents and induces striatal increases of neurotrophic > factors.Diethyldithiocarbamate (ethyl carbamate) a caspase inhibitor > enhanced 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine or MPTP toxicity. > MPTP toxicity from synthetic demerol caused Parkinsons disease in those who > took the drug. Effecting NMDA receptors. > 30. Retinoid Signaling Pathways by Jetten, A. Actions of certain retinoids > not mediated by RAR and RXR retinoid receptors such as AHPN. Overexpression > of lymphoma cells is accompanied by caspase-3 activity. SVAD-fmk inhibited > cell death but did not affect induction of growth arrest. ZVAD-fmk was used > as a trial to inhibit Caspase-1 in Huntington's disease. AHPN or > 6-3-1-adamantyl-4-hydroxy-phenyl-2-naphthalene-carboxylic acid would be > metabolized by the tricarboxylic acid cycle, cAMP,CREB,CREB2,CCAAT. > 4HNE mutation causes Parkinsons disease. PMID 8687011 Accumulation of > deletions and point mutations in mitochondrial genome in degenerative > diseases. > 31. Interaction between the components of the human NADPH oxidase: A review > about the intrigues in the PHOX family - Emma's Children Hospital, Academic > Medical Center, Amsterdam, The Netherlands. Rap1 becomes phosphorylated by > the cAMP dependent PKA . A serine residue at the COOH-terminal region of > RAP1A has been identified as a site of phosphorylation by PKA. It is > possible that phosphorylation of Rap1A regulates the deactivation of NADPH > oxidase. Rap1 effects cytochrome b 558. NADPH oxidase is a rasrelated > protein called rac. > 32.PMID 602048 Ras-related C3 Botulinum Toxin substrate; RAC1 regulates > cell growth, cytoskeletal reorganization, and the activation of protein > kinases. Rac1 and Rac2 idntify with RHOS and RAS respectively. The 2 genes > encode the C-terminal consensus sequence (CXXX-COOH). Rac1 is essential for > nuclear factor kapaB/rel-dependent transcriptional regulation of > interleukin-1-alpha, which in an autocrine manner, induced collagenase-1 > gene expression. > 33. PMID 6952245 Cloned cDNA sequences of the hypoxanthine/guanine > phosphoribosyltransferese gene from mouse neuroblasotma cell line found to > have amplified genomic sequences. (HPRT gene color blindness - increased > HPRT protein) > [log in to unmask]