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---------- > From: [log in to unmask] > To: [log in to unmask] > Cc: [log in to unmask] > Subject: Parkinsons Disease and Environmental Botulism > Date: Sunday, July 04, 1999 11:58 AM > > I am writing to you because your name was given to me by our MD who said > you were connected with the Harvard Health Letter. There is a disease > where muscles grind to a halt, the eyelids droop, then it becomes more > and more difficult to swallow, and to breathe and then you die. Sounds > like Parkinsons, but its botulism. Clostridium botulinum lives in the > soil, it makes nitroso, dimethylbutyrate, amines that live in sludge and > sewers and old smoked food. N-nitrosodimethylamine and dimethylamine > that becomes N-nitrosodimethylamine in air are found in diesel and gas > exhaust, pesticide propellant, food, meat packaging, infant formula, and > many other places. They are a cRA or 13-cis-retinoid that has caused > craniofacial mutation in animals. Clostridium botulinum effects > breakpoint clusters that happen when there is an environmental cause of > a genetic disease. N-nitrosomethylurea causes breast cancer. > Parkinsonians often have craniofacial birth defects like blue-yellow > color blindness and olfactory (an unusual smell of which they can > predict future parkinsonians in families). My husband has Parkinsons. > His fraternal twin has breast cancer. I think I have found the > environmental cause of Parkinsons disease. The other reason I am > writing, is that retinoid X mutant mice have a parkinsonian locomotion > and Targretin is a new drug put out by Ligand Pharmaceuticals for breast > cancer, diabetes type two, often associated with Parkinsons, which my > husband has, and for psoriasis which my husband has. I think he really > needs the retinoid CREB2, but this targretin would help for now, and the > company has other retinoid drugs in the works. The company has no plans > to try it for Parkinsons. From what I understand, Parkinsons is an > overproduction of cAMP which the retinoid CREB inhibits, and it is an > overproduction of lipid peroxidation which CREB2 would inhibit since it > is often associated with C/EBP or the myeloperoxidase promoter. They are > using BOTOX treatments for dystonia in parkinsons. I think they are > giving Parkinsons shots really , more N-nitrosodimethylamine to really > kill the muscle and deaden the effects of acetylcholine. It does help > the pain and spasms. Slowly the brain cells are dying and there is less > CREB2. Also butyrate increases tumor formation, maybe lewy bodies. > Dimethylamine inhibits Transglutaminase activity that connects to AAT, > and there is an AAT Parkinsons disease. Dimethylamine also inhibits > glucose-stimulated insulin release, causing diabetes type two, and > amines form complexes with metallic ions, maybe this might explain > Alzheimers and aluminum, Parkinsons and a low zinc level. Parkinsonians > also have elevated T-cells. I have scientific papers at home to back > this up. We live outside of Boston. Thanks for listening. > [log in to unmask]