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> Just a perhaps silly question: if dyskinesia can be a sign of too much > L-dopa, what are the signs of too much agonist? > Maryse Not a silly question at all Maryse. In my experience OD'ing on an agonist (in my case Permax) leads to painful contractions of the facial muscles. This gives the impression that you are snarling (or grinning wolfishly if you prefer). It has also been my experience that dyskinesia can be reduced by lowering the amount of agonist being taken. My speculation is that the presence of the agonist reduces the amount of levodopa required. Dennis +++++++++++++++++++++++++++ Dennis Greene 49/dx 37/ onset 32 There's nothing wrong with me that a cure for PD won't fix! [log in to unmask] http://members.networx.net.au/~dennisg/ +++++++++++++++++++++++++++