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---------- > From: Sharon & Jim LeBlanc <[log in to unmask]> > To: [log in to unmask] > Subject: Sixth References for Environmental Parkinsons - Pollutant Botulism - Clostridium Botulinum > Date: Tuesday, July 06, 1999 8:36 AM > > > Theory > > Parkinsons and Huntington's Diseases Compared > Go around the loop > [log in to unmask] > THE LOOP > > PARKINSONS - NADH-CoQ10 > Complexes > NADPH-NADH-COMPLEX I - NADH OXIDASE -RAC-RAC3- > Clostridium Botulinum > > HUNTINGTONS > GAPDH-GAPD-DRPLA > > ACTIN APP (Amyloid > Precursor Protein) > CAP FE 65 > DYNACTIN p50 - p150 WWW DOMAIN (HYPA,HYPB,HYPC) > HAP1 HAP1A, HAP2A, HAP3A > HUNTINGTIN HUNTINGTIN > HIP2 Albumin Promoter D > - 3 domains > UBIQUITIN E2-25K CCAAT (CP1,CP2,CTF/NF1) > (CUTL1) cuts protein > CASPASE-1 CASPASE-1 > NF/Y - beta actin AAT - > Alpha-1-antitrypsin prealbumin protease inhibitor > NFKB1 - Proteasome 26S GLU342 bile salt > NFKappaB/Rel -PARKINSONS Gammaglutamyl transferase > Dynactin p50-p150 - HAP1 Transglutaminase - flutamine > residues of CAG Huntington's Disease > HUNTINGTIN HUNTINGTIN > > > Too much Huntingtin in HUNTINGTON's Disease > Normal in most people > > HUNTINGTIN a subset of TRANSGLUTAMINASE inhibited by RRE-1 and HR1 > Retinoids - Good future treatment > TRANSGLUTAMINASE inhibited by Dimethylamine and N-nitrosodimethylamine - > PARKINSONS DISEASE >