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Re. amandatine(symmetrel). i have direct contact with parkinson for the last 29 years. when leahy clinic first diagnosed parkinson, the only medication offered was symmetrel. my observation confirmed many times that the most erroneous treatment by the medical profession is the lack of explanation between the inter relationship of agonists and inhibitors to sinemet. Professor Birkmayer, the leading Parkinson specialist in the world, always maintained that proper treatment of PD necessitates a close explanatory relationship between doctor, caregiver and patient. Unfortunately too many of our "specialists" fail to live up to that credence. insist that your doctor explain to you why and how you should combine agonists and inhibitors with your sinemet and the vast difference in effectiveness between regular sinemet and sinemet CR when related to agonists and inhibitors. Many PD's could greatly enhance their physical well-being through proper experimentation with various combination of inhibitors and agonists. In my case after 29 years of PD the person is 75% mobile, practically without dyskenesia and functioning. I am glad I spent so much time with Professor Birkmayer to learn the basic problems of PD and how to solve them.